Imerslund-Gräsbeck Syndrome

Also known as Cobalamin Malabsorption or Vitamin B12 Deficiency.

Imerslund-Gräsbeck Syndrome: Affected pups typically fail to thrive and have anaemia, poor appetite, poor growth, weakness and intermittent diarrhoea. The non-specific nature of these signs probably means that the condition often goes undiagnosed. The basis for the condition is an inherent inability to absorb vitamin B12 in the digestive tract; these clinical signs can be ameliorated by regular injections of vitamin B12.

Imerslund-Gräsbeck Syndrome is caused by a recessive genetic mutation. This means that dogs which carry the mutation (“CARRIERS”) are normal but will pass the mutation on to an average of 50% of their offspring. Puppies which inherit two copies of the mutation will have Imerslund-Gräsbeck Syndrome (“AFFECTED”).

This test is particularly useful for breeders:

  • To identify carriers among their breeding stock so that they can avoid CARRIER X CARRIER mating combinations which would risk AFFECTED puppies.
  • To conclusively confirm Imerslund-Gräsbeck Syndrome in an affected dog

Animal DNA Diagnostics Ltd, who work with the Society extracting DNA for CEA and Parent Profiling Tests offers the test for Imerslund-Gräsbeck Syndrome in the Border Collie. The test is available to order from their website  - just click on "I require a DNA test for a dog" and the website will lead you through the ordering process. The test costs £40 + VAT, and is performed using mouth swabs which they will post out to you. 

 

 

 

Laboklin laboratories also offer this test to members, with a 10% discount through their website

 

 

 

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